Pancof HC

Generic Name: hydrocodone and pseudoephedrine (Oral route)

hye-droe-KOE-done bye-TAR-trate, soo-doe-e-FED-rin hye-droe-KLOR-ide

Commonly used brand name(s)

In the U.S.

• Pancof HC


• Rezira

Available Dosage Forms:

• Solution


• Liquid


• Syrup


• Tablet

Therapeutic Class: Antitussive, Opioid/Decongestant Combination

Pharmacologic Class: Pseudoephedrine

Chemical Class: Hydrocodone

Uses For Pancof HC

Hydrocodone and pseudoephedrine combination is used in adults 18 years of age and older to relieve cough and nasal congestion (stuffy nose) caused by the common cold.

Hydrocodone is a narcotic antitussive (cough suppressant). It acts directly on the cough center in the brain to relieve cough. Pseudoephedrine is a decongestant, which decreases nasal congestion by narrowing the blood vessels and reducing blood flow to the nasal passage.

When hydrocodone is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing cough and nasal congestion should not let the fear of dependence keep them from using narcotics to relieve their cough. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only with your doctor's prescription.

Before Using Pancof HC

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of hydrocodone and pseudoephedrine combination is not indicated in children younger than 18 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydrocodone and pseudoephedrine combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Clorgyline


• Dihydroergotamine


• Furazolidone


• Iproniazid


• Isocarboxazid


• Linezolid


• Moclobemide


• Naltrexone


• Nialamide


• Pargyline


• Phenelzine


• Procarbazine


• Rasagiline


• Selegiline


• Toloxatone


• Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adinazolam


• Alfentanil


• Alprazolam


• Amobarbital


• Anileridine


• Aprobarbital


• Bromazepam


• Brotizolam


• Buprenorphine


• Butabarbital


• Butalbital


• Butorphanol


• Carisoprodol


• Chloral Hydrate


• Chlordiazepoxide


• Chlorzoxazone


• Clobazam


• Clonazepam


• Clorazepate


• Codeine


• Dantrolene


• Dezocine


• Diazepam


• Estazolam


• Ethchlorvynol


• Fentanyl


• Flunitrazepam


• Flurazepam


• Fospropofol


• Guanethidine


• Halazepam


• Hydrocodone


• Hydromorphone


• Ketazolam


• Levorphanol


• Lorazepam


• Lormetazepam


• Medazepam


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Methyldopa


• Midazolam


• Midodrine


• Morphine


• Morphine Sulfate Liposome


• Nalbuphine


• Nitrazepam


• Nordazepam


• Opium


• Oxazepam


• Oxycodone


• Oxymorphone


• Pentazocine


• Pentobarbital


• Phenobarbital


• Prazepam


• Propoxyphene


• Quazepam


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Tapentadol


• Temazepam


• Thiopental


• Triazolam

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Escitalopram

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Addison's disease (adrenal gland problem) or


• Asthma or


• Diabetes or


• Drug dependence, especially narcotic abuse or dependence, or history of or


• Enlarged prostate (BPH, prostatic hypertrophy) or


• Problems with passing urine or


• Thyroid disease—Use with caution. May increase risk for more serious side effects.

• Heart disease (e.g., coronary artery disease), severe or


• Hypertension (high blood pressure), severe or


• Narrow angle glaucoma or


• Urinary retention—Should not be used in patients with these conditions.

• Kidney disease, severe or


• Liver disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of hydrocodone and pseudoephedrine

This section provides information on the proper use of a number of products that contain hydrocodone and pseudoephedrine. It may not be specific to Pancof HC. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

Measure the oral liquid correctly using the marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Ask your pharmacist for instructions for measuring the correct dose of this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (solution):
  
  • For relief of cough and nasal congestion:
    
    • Adults—5 milliliters (mL) every 4 to 6 hours as needed. However, the dose is usually not more than 4 doses (20 mL) in 24 hours.
    
    
    • Children—Use is not recommended.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Pancof HC

It is very important that your doctor check your progress while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. If your symptoms do not improve or if they get worse, call your doctor.

Do not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days.

Symptoms of an overdose include: extreme dizziness or weakness, shortness of breath, slow heartbeat or breathing, seizures, and cold, clammy skin. In case of an overdose, call your doctor right away.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

This medicine may make you dizzy or drowsy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using this medicine.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn babies. Tell your doctor right away if your child has the following symptoms: abnormal sleep pattern, diarrhea, fever, high-pitched cry, irritability, shakiness or tremor, vomiting, weight loss, or failure to gain weight.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Pancof HC Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Blurred vision


• confusion


• dizziness


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• fainting


• fast, slow, or irregular heartbeat


• sweating


• unusual tiredness or weakness

Incidence not known

• Abdominal or stomach cramps or pain


• bloating


• bulging soft spot on the head of an infant


• change in the ability to see colors, especially blue or yellow


• convulsions


• decrease in the frequency of urination


• decrease in urine volume


• diarrhea


• difficult or painful urination


• difficult or troubled breathing


• difficulty having a bowel movement (stool)


• difficulty in passing urine (dribbling)


• drowsiness


• frequent urge to urinate


• headache


• irregular, fast or slow, or shallow breathing


• loss of appetite


• nervousness


• pale or blue lips, fingernails, or skin


• pounding in the ears


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• sleeplessness


• trembling or shaking of the hands or feet


• trouble with sleeping


• unable to sleep


• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Fear


• mood changes


• nausea


• relaxed and calm


• sleepiness


• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Incidence not known

• Itching skin


• skin rash


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Pancof HC side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Pancof HC resources

• Pancof HC Side Effects (in more detail)
• Pancof HC Use in Pregnancy & Breastfeeding
• Pancof HC Drug Interactions
• Pancof HC Support Group
• 0 Reviews for Pancof HC - Add your own review/rating

• Detussin Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• Rezira Prescribing Information (FDA)


• Rezira Consumer Overview

Compare Pancof HC with other medications

• Cough and Nasal Congestion

Equell

Dosage Form: FOR ANIMAL USE ONLY
Equell®

(ivermectin)

Paste 1.87%

Anthelmintic and Boticide

FOR ORAL USE IN HORSES ONLY

Removes worms and bots with a single dose.

Contents will treat up to 1320 lb body weight.

Net Weight: 0.225 oz (6.42 g)

INDICATIONS

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. Equell (ivermectin) Paste provides effective control of the following parasites in horses:

Large Strongyles (adults)

  Strongylus vulgaris (also early forms in blood vessels)

  S. edentatus (also tissue stages)

  S. equinus

  Triodontophorus spp. including T. brevicauda, T. serratus

  Craterostomum acuticaudatum

Small Strongyles (adults, including those resistant to some benzimidazole class compounds)

  Coronocyclus spp. including C. coronatus, C. labiatus and C. labratus

  Cyathostomum spp. including C. catinatum, C. pateratum

  Cylicocyclus spp. including C. insigne, C. leptostomum, C. nassatus, C. brevicapsulatus

  Cylicostephanus spp. including C. calicatus, C. goldi, C. longibursatus, C. minutus

  Cylicodontophorus spp.

  Petrovinema poculatum

Small Strongyles (fourth-stage larvae)

Pinworms (adults and fourth-stage larvae)

  Oxyuris equi

Ascarids (adults and third- and fourth-stage larvae)

  Parascaris equorum

Hairworms (adults)

  Trichostrongylus axei

Large-mouth Stomach Worms (adults)

  Habronema muscae

Bots (oral and gastric stages)

  Gasterophilus spp. including G. intestinalis and G. nasalis

Lungworms (adults and fourth-stage larvae)

  Dictyocaulus arnfieldi

Intestinal Threadworms (adults)

  Strongyloides westeri

Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae

Dermatitis caused by Neck Threadworm microfilariae, Onchocerca sp.

Equell Dosage and Administration

This syringe contains sufficient paste to treat one 1320-lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) of body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb (114 kg) of body weight.

1. While holding plunger, turn the knurled ring on the plunger 1/4 turn to the left and slide it so the side nearest the barrel is at the prescribed weight marking.


2. Lock the ring in place by making a 1/4 turn to the right.


3. Make sure that the horse’s mouth contains no feed.


4. Remove the cover from the tip of the syringe.


5. Insert the syringe tip into the horse’s mouth at the space between the teeth.


6. Depress the plunger as far as it will go, depositing paste on the back of the tongue.


7. Immediately raise the horse's head for a few seconds after dosing.

Parasite Control Program

All horses should be included in a regular parasite control program with particular attention being paid to mares, foals, and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. Equell Paste effectively controls gastrointestinal nematodes and bots of horses. Regular treatment will reduce the chances of verminous arteritis caused by Strongylus vulgaris.

Product Advantages

Broad-spectrum Control

Equell Paste kills important internal parasites, including bots and the arterial stages of S. vulgaris, with a single dose. Equell Paste is a potent antiparasitic agent that is neither a benzimidazole nor an organophosphate.

ANIMAL SAFETY

Equell Paste may be used in horses of all ages, including mares at any stage of pregnancy. Stallions may be treated without adversely affecting their fertility.

Warnings

Do not use in horses intended for human consumption.

Not for use in humans. Keep this and all drugs out of reach of children. Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes.

The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. To report adverse reactions in users, to obtain more information, or to obtain a MSDS, contact Bimeda, Inc. at 1-888-524-6332.

Precautions

Equell Paste has been formulated specifically for use in horses only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.

Environmental Safety

Ivermectin and excreted ivermectin residues may adversely affect aquatic organisms. Do not contaminate ground or surface water. Dispose of the syringe in an approved landfill or by incineration.

Store at room temperature (25°C/77°F), with excursions permitted between 15°- 30°C (59°- 86°F).

INFORMATION FOR HORSE OWNERS

Swelling and itching reactions after treatment with ivermectin paste have occurred in horses carrying heavy infections of neck threadworm (Onchocerca sp. microfilariae). These reactions were most likely the result of microfilariae dying in large numbers. Symptomatic treatment may be advisable. Consult your veterinarian should any such reactions occur. Healing of summer sores involving extensive tissue changes may require other appropriate therapy in conjunction with treatment with Equell Paste. Reinfection, and measures for its prevention, should also be considered. Consult your veterinarian if the condition does not improve.

ANADA 200-320, Approved by FDA

Manufactured by:

Virbac AH Inc.

3200 Meacham Blvd

Fort Worth, Texas 76137

Distributed by:

Bimeda, Inc.

Le Sueur, MN 56058

Equell is a Registered Trademark of Virbac SA.

November 2009

301981-01

PRINCIPAL DISPLAY PANEL - 6.42 g Syringe Carton

Equell®

(ivermectin)

Paste 1.87%

Anthelmintic and Boticide

Removes worms and bots with a single dose.

Contents will treat up to 1320 lb. body weight.

FOR ORAL USE IN HORSES ONLY

Net Weight: 0.225 oz (6.42 g)

ANADA 200-320, Approved by FDA

Bimeda

Equell  ivermectin  paste

Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 61133-7010 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Ivermectin (Ivermectin) Ivermectin 200 ug

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color WHITE Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 61133-7010-1 1 SYRINGE In 1 CARTON None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANADA	ANADA200320	01/14/2010

Labeler - Bimeda Inc (043653216)

Registrant - Virbac AH Inc (131568396)

Establishment
Name	Address	ID/FEI	Operations
Virbac Bridgeton		808558100	MANUFACTURE

Revised: 01/2010Bimeda Inc

Carbidopa/Entacapone/Levodopa

Pronunciation: KAR-bi-DOE-pa/LEE-voe-DOE-pa/en-TAK-a-pone
Generic Name: Carbidopa/Levodopa/Entacapone
Brand Name: Stalevo

Carbidopa/Entacapone/Levodopa is used for:

Treating symptoms of Parkinson disease.

Carbidopa/Entacapone/Levodopa is an antidyskinetic combination of dopamine-enhancing medicines. It works by increasing the amount of dopamine in the brain. By increasing the amount of dopamine in the brain, the chemicals of the brain become more balanced and the symptoms of this disease are lessened.

Do NOT use Carbidopa/Entacapone/Levodopa if:

• you are allergic to any ingredient in Carbidopa/Entacapone/Levodopa


• you have narrow-angle glaucoma, skin growths of unknown cause, skin cancer, or a history of skin cancer


• you have taken furazolidone or certain monoamine oxidase inhibitors (MAOIs) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Carbidopa/Entacapone/Levodopa:

Some medical conditions may interact with Carbidopa/Entacapone/Levodopa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of heart problems (eg, irregular heartbeat) or a heart attack, blood pressure problems, endocrine problems, fainting, lung problems (eg, asthma), kidney or liver problems, neuroleptic malignant syndrome (NMS), a severe muscle problem called rhabdomyolysis, glaucoma or increased pressure in the eye, or mood or mental problems (eg, depression)


• if you have stomach or intestinal problems (eg, ulcers), or biliary or gallbladder problems

Some MEDICINES MAY INTERACT with Carbidopa/Entacapone/Levodopa. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Furazolidone, MAOIs (eg, phenelzine), selegiline, or tricyclic antidepressants (eg, amitriptyline) because serious side effects (eg, headache, very high blood pressure, abnormal heartbeat) may occur


• Ampicillin, chloramphenicol, cholestyramine, erythromycin, metoclopramide, probenecid, rifampin, or sympathomimetics (eg, phenylephrine) because they may increase the risk of Carbidopa/Entacapone/Levodopa's side effects


• Apomorphine, butyrophenones (eg, haloperidol), hydantoins (eg, phenytoin), isoniazid, metoclopramide, papaverine, phenothiazines (eg, chlorpromazine), or risperidone because they may decrease Carbidopa/Entacapone/Levodopa's effectiveness


• Medicines for blood pressure because the risk of their side effects may be increased by Carbidopa/Entacapone/Levodopa


• Digoxin and iron salts (eg, ferrous sulfate) because their effectiveness may be decreased by Carbidopa/Entacapone/Levodopa

This may not be a complete list of all interactions that may occur. Ask your health care provider if Carbidopa/Entacapone/Levodopa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Carbidopa/Entacapone/Levodopa:

Use Carbidopa/Entacapone/Levodopa as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Carbidopa/Entacapone/Levodopa by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Swallow Carbidopa/Entacapone/Levodopa whole. Do not break, crush, or chew before swallowing.


• Take Carbidopa/Entacapone/Levodopa at least 4 hours before or after taking iron salts (eg, ferrous sulfate).


• Diets that are high in protein may decrease your body's ability to absorb Carbidopa/Entacapone/Levodopa. Discuss any questions or concerns with your doctor. Tell your doctor if you have a diet that is high in protein, or if you will be changing your diet to include more protein.


• Do not suddenly stop taking Carbidopa/Entacapone/Levodopa without checking with your doctor. Side effects may occur. They may include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating.


• If you miss a dose of Carbidopa/Entacapone/Levodopa, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Carbidopa/Entacapone/Levodopa.

Important safety information:

• Carbidopa/Entacapone/Levodopa may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Carbidopa/Entacapone/Levodopa with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Carbidopa/Entacapone/Levodopa; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Carbidopa/Entacapone/Levodopa may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Diets high in protein may prevent your body's ability to absorb Carbidopa/Entacapone/Levodopa. Dietary protein should be eaten evenly throughout the day.


• Gradually increase physical activity as your symptoms improve.


• A "wearing-off" effect may occur before you need to take your next dose of Carbidopa/Entacapone/Levodopa. If this effect becomes bothersome, contact your doctor.


• Carbidopa/Entacapone/Levodopa may cause diarrhea. It typically begins within 4 to 12 weeks of starting Carbidopa/Entacapone/Levodopa, but may occur during the first week or many months after starting it. Rare cases of prolonged diarrhea caused by colitis (inflammation of the large intestine) have occurred in patients taking Carbidopa/Entacapone/Levodopa. Contact your doctor if you have severe, persistent, or watery diarrhea.


• If diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.


• Carbidopa/Entacapone/Levodopa may discolor the saliva, urine, or sweat a dark color (red, brown, or black). This is normal and not a cause for concern.


• Carbidopa/Entacapone/Levodopa may cause nausea, especially when you first start to take it. Check with your doctor if nausea persists or is severe.


• Carbidopa/Entacapone/Levodopa may cause mental or mood changes. Contact your doctor at once if any new or worsening symptoms such as depressed mood; anxious, restless, or irritable behavior; or unusual changes in mood or behavior occur. Contact your doctor right away if any signs of suicidal thoughts or actions occur.


• You may experience an increase in involuntary movements while taking Carbidopa/Entacapone/Levodopa. Check with your doctor if this occurs.


• NMS is a possibly fatal syndrome that can be caused by Carbidopa/Entacapone/Levodopa. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.


• Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using Carbidopa/Entacapone/Levodopa. Tell your doctor right away if you notice such effects.


• Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if Carbidopa/Entacapone/Levodopa also increases the risk of melanoma. You may need to have skin exams while you are using Carbidopa/Entacapone/Levodopa. Discuss any questions or concerns with your doctor.


• Tell your doctor or dentist that you take Carbidopa/Entacapone/Levodopa before you receive any medical or dental care, emergency care, or surgery.


• Diabetes patients - Carbidopa/Entacapone/Levodopa may cause the results of some tests for urine glucose or urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.


• Carbidopa/Entacapone/Levodopa may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Carbidopa/Entacapone/Levodopa.


• Lab tests, including complete blood cell counts and heart, liver, and kidney function, may be performed while you use Carbidopa/Entacapone/Levodopa. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Carbidopa/Entacapone/Levodopa with extreme caution in the ELDERLY; they may be more sensitive to its effects.


• Carbidopa/Entacapone/Levodopa should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Carbidopa/Entacapone/Levodopa while you are pregnant. It is not known if Carbidopa/Entacapone/Levodopa is found in breast milk. If you are or will be breast-feeding while you use Carbidopa/Entacapone/Levodopa, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Carbidopa/Entacapone/Levodopa:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Change in taste; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; dark urine; depression with thoughts of suicide; fainting; fast or irregular heartbeat; fever; hallucinations; lack of response to environment; mental or mood changes; muscle pain, stiffness, or rigidity; new or increased involuntary movements; paranoia; seizures; severe or persistent dizziness; severe, persistent, or watery diarrhea; shortness of breath; stomach pain; trouble sleeping; unusual or painful movements of the face, eyelids, mouth, tongue, arms, hands, or legs; unusual skin growths or change in the appearance of a mole; unusual sweating; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Carbidopa/Entacapone/Levodopa side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; confusion; dark urine or trouble urinating; fast or irregular heartbeat; high blood pressure; insomnia; muscle spasms; restlessness.

Proper storage of Carbidopa/Entacapone/Levodopa:

Store Carbidopa/Entacapone/Levodopa at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Protect from heat, moisture, and light. Keep in a tight, light-resistant container. Do not store in the bathroom. Keep Carbidopa/Entacapone/Levodopa out of the reach of children and away from pets.

General information:

• If you have any questions about Carbidopa/Entacapone/Levodopa, please talk with your doctor, pharmacist, or other health care provider.


• Carbidopa/Entacapone/Levodopa is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Carbidopa/Entacapone/Levodopa. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Carbidopa/Entacapone/Levodopa resources

• Carbidopa/Entacapone/Levodopa Side Effects (in more detail)
• Carbidopa/Entacapone/Levodopa Dosage
• Carbidopa/Entacapone/Levodopa Use in Pregnancy & Breastfeeding
• Carbidopa/Entacapone/Levodopa Drug Interactions
• Carbidopa/Entacapone/Levodopa Support Group
• 5 Reviews for Carbidopa/Entacapone/Levodopa - Add your own review/rating

• Stalevo 100 Concise Consumer Information (Cerner Multum)


• Stalevo 100 Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Carbidopa/Entacapone/Levodopa with other medications

• Parkinson's Disease

Phosex 1000mg Tablets

1. Name Of The Medicinal Product

Phosex® 1000 mg tablet

2. Qualitative And Quantitative Composition

1 tablet contains

Calcium Acetate 1000 mg (calcium acetate anhydrous 986.36 mg) equivalent to 250 mg calcium.

For a full list of excipients see Section 6.1.

3. Pharmaceutical Form

Tablet

Oval yellow tablet embossed “PHOS-EX” on one side with a score-line on the reverse

4. Clinical Particulars

4.1 Therapeutic Indications

Correction of hyperphosphataemia associated with chronic renal failure in patients undergoing dialysis.

4.2 Posology And Method Of Administration

For oral use

Initially one tablet 3 times a day. The tablet should be swallowed whole with a meal to achieve the maximal phosphate binding effect. Where the patient cannot swallow the tablets whole they may be broken and taken with food. Tablets, whether whole or broken, should not be chewed due to their bitter taste. The dose can be increased until the desired serum phosphate level is achieved, as long as hypercalcaemia does not occur. Most patients need 4 to 6 tablets per day (1 to 2 tablets with each meal).

The maximum recommended daily dose is 12 tablets.

4.3 Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Hypercalcaemia.

4.4 Special Warnings And Precautions For Use

The use of phosphate binders in renal failure should be in conjunction with dietary advice regarding phosphate intake and methods of dialysis appropriate to the patient.

The dose will need to be adjusted depending on phosphate intake or removal by dialysis and on the ensuing effect on serum calcium. This requires regular monitoring, for example weekly, of both the serum phosphate and calcium levels to determine efficacy and prevent hypercalcaemia.

If hypercalcaemia occurs, the dosage should be reduced or the treatment withdrawn temporarily, depending on the degree of hypercalcaemia. The risk of hypercalcaemia needs to be considered particularly during concomitant treatment with Vitamin D preparations.

The concomitant administration of calcium and vitamin D derivatives is to be made under the supervision of a physician.

Patients suffering with progressive renal failure may exhibit signs of, and should be warned of the symptoms of, hypercalcaemia, ectopic or vascular calcification, or adynamic bone disease. Regular monitoring is required since caution is needed in administering Phosex® under these circumstances.

The long-term toxicity of Phosex® has not been evaluated in clinical trials. In particular during long-term phosphate binding therapy with calcium salts there have been reports of tissue calcifications. It is not known whether the risk of calcification is higher with Phosex® than with other calcium salts.

Patients should be advised to seek medical advice before taking non-prescription antacids containing calcium carbonate or other calcium salts to avoid adding to the calcium load.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Calcium interacts with several drugs:

- The absorption of antibiotics such as ciprofloxacin, enoxacin, norfloxacin, tetracyclines (PO) can be affected and consequently, the intake of Phosex® should be made 3 hours before or after the antimicrobial treatment.

- Vitamin D preparations may require dosage modification to avoid hypercalcaemia.

- Digitalis glycosides, verapamil and gallopamil in the presence of hypercalcaemia can enhance cardiac effects and can lead to cardiac toxicity. Therefore, special precautions for use (ECG and biological surveillance) are to be taken.

4.6 Pregnancy And Lactation

No data available. It is not known whether Phosex® can cause foetal effects when administered during pregnancy or whether it can affect reproductive capacity.

Phosex® should only be administered to pregnant or lactating women if it is clearly indicated.

4.7 Effects On Ability To Drive And Use Machines

No effects on the ability to drive and use machines have been observed.

4.8 Undesirable Effects

Uncommon (0.1%

Hypercalcaemia can occur and the serum levels of total and ionised calcium should be monitored. Mild hypercalcaemia (Ca>2.6 mmol/L) may occur in about 1% of patients and may be asymptomatic or manifest itself as constipation, anorexia, nausea and vomiting. More severe hypercalcaemia (Ca>3.0 mmol/L) may occur in about 0.1% of patients and can be associated with confusion, delirium, stupor and in very severe cases coma. Patients should be advised to consult their doctor if any of these symptoms occur.

4.9 Overdose

Overdose with calcium substances may lead to soft tissue calcifications.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Pharmacotherapeutic group: Drugs for treatment of hyperkalaemia and hyperphosphataemia

ATC code: V03A E

Phosphate binder.

Calcium ions of calcium acetate interact with and bind to phosphates in the gastro-intestinal tract to form calcium phosphate an insoluble or partially soluble product, which is excreted in the faeces.

Both components of Phosex®, calcium and acetate, are normal physiological components of the body and are also present in food. As a naturally occurring food constituent, calcium acetate is generally regarded as safe. However, excessive intake of calcium salts can result in hypercalcaemia.

5.2 Pharmacokinetic Properties

Calcium acetate is not indicated for systemic availability. The residual acetate will be metabolised through bicarbonate, which will be further excreted via normal metabolic routes.

The amount of calcium not involved in the binding of phosphate is variable and any unbound calcium may be absorbed. Therefore regular monitoring of calcium levels is recommended.

5.3 Preclinical Safety Data

No specific studies are available on Phosex® calcium acetate tablets.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Macrogol 8000

Sodium starch glycolate (type A)

Calcium stearate

Lemon meringue flavour containing lemon oil, citral, aldehyde C-9, lime oil, orange oil, vanillin, ethyl vanillin, malto-dextrin, tricalcium phosphate

Yellow iron oxide (E172)

6.2 Incompatibilities

Not applicable.

6.3 Shelf Life

3 years.

6.4 Special Precautions For Storage

Do not store above 25°C.

Store Phosex® in the original container and keep the container tightly closed in order to protect from moisture.

6.5 Nature And Contents Of Container

White HDPE bottles with polypropylene caps.

Package size: bottle with 50, 100, 180, 200, 500 tablets.

Not all pack sizes may be marketed.

6.6 Special Precautions For Disposal And Other Handling

No special requirements.

7. Marketing Authorisation Holder

Vitaline Pharmaceuticals UK Limited

Chiltern House

Unit P, Howland Road

Thame

Oxon

OX9 3GQ

UK

8. Marketing Authorisation Number(S)

PL 14994/0001

9. Date Of First Authorisation/Renewal Of The Authorisation

22 December 1997/21 December 2002/22 December 2007

10. Date Of Revision Of The Text

May 2010

Pyrantel Pamoate

Pronunciation: pi-RAN-tel
Generic Name: Pyrantel Pamoate
Brand Name: Reese's Pinworm Medicine

Pyrantel Pamoate is used for:

Treating certain worm infections (eg, pinworm, roundworm).

Pyrantel Pamoate is an anthelmintic agent. It works by paralyzing the nervous system of intestinal parasites (worms). The parasite is then passed in the stool.

Do NOT use Pyrantel Pamoate if:

• you are allergic to any ingredient in Pyrantel Pamoate


• you have liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pyrantel Pamoate:

Some medical conditions may interact with Pyrantel Pamoate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have worms other than pinworms


• if others in your home also have pinworms

Some MEDICINES MAY INTERACT with Pyrantel Pamoate. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Piperazine because the effectiveness of Pyrantel Pamoate may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pyrantel Pamoate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pyrantel Pamoate:

Use Pyrantel Pamoate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Pyrantel Pamoate may be taken on an empty stomach or with food, milk, or juice.


• Wear tight underwear both day and night while taking Pyrantel Pamoate.


• Pyrantel Pamoate is usually prescribed as a single dose.


• Only one dose of Pyrantel Pamoate is required. If you forget to take Pyrantel Pamoate, take it as soon as you remember.

Ask your health care provider any questions you may have about how to use Pyrantel Pamoate.

Important safety information:

• Pyrantel Pamoate may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Pyrantel Pamoate. Using Pyrantel Pamoate alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• This infection spreads easily to family members and close contacts. To prevent reinfection: Disinfect toilet and change and wash underwear, bed linens, towels, clothes, and pajamas daily. Wash hands with soap often during the day, especially before eating and after using the toilet. Do not scratch the infected area or place your fingers in your mouth.


• The entire household should be treated with Pyrantel Pamoate if one individual in the household has pinworms.


• After treatment with Pyrantel Pamoate, clean the bedroom floor by vacuuming or damp mopping.


• If any worms other than pinworms are visible after treatment with Pyrantel Pamoate, contact your doctor.


• Use Pyrantel Pamoate with extreme caution in CHILDREN younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Pyrantel Pamoate, discuss with your doctor the benefits and risks of using Pyrantel Pamoate during pregnancy. It is unknown if Pyrantel Pamoate is excreted in breast milk. If you are or will be breast-feeding while you are using Pyrantel Pamoate, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Pyrantel Pamoate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; headache; loss of appetite; nausea; stomach cramps; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Pyrantel Pamoate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Pyrantel Pamoate:

Store Pyrantel Pamoate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pyrantel Pamoate out of the reach of children and away from pets.

General information:

• If you have any questions about Pyrantel Pamoate, please talk with your doctor, pharmacist, or other health care provider.


• Pyrantel Pamoate is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pyrantel Pamoate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Pyrantel Pamoate resources

• Pyrantel Pamoate Side Effects (in more detail)
• Pyrantel Pamoate Dosage
• Pyrantel Pamoate Use in Pregnancy & Breastfeeding
• Pyrantel Pamoate Drug Interactions
• Pyrantel Pamoate Support Group
• 0 Reviews for Pyrantel Pamoate - Add your own review/rating

• Pyrantel Pamoate Monograph (AHFS DI)


• Antiminth Concise Consumer Information (Cerner Multum)


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Cordran Lotion

Pronunciation: FLUR-an-DREN-oh-lide
Generic Name: Flurandrenolide
Brand Name: Cordran

Cordran Lotion is used for:

Treating inflammation and itching due to certain skin conditions. It may also be used for other conditions as determined by your doctor.

Cordran Lotion is a topical adrenocortical steroid. It works by reducing skin inflammation (redness, swelling, itching, and irritation) in a way that is not clearly understood.

Do NOT use Cordran Lotion if:

• you are allergic to any ingredient in Cordran Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cordran Lotion:

Some medical conditions may interact with Cordran Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin


• if you have had a recent vaccination; have measles, tuberculosis (TB), chickenpox, or shingles; or have had a positive TB test


• if you are taking prednisone or similar medicines

Some MEDICINES MAY INTERACT with Cordran Lotion. Because little, if any, of Cordran Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cordran Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cordran Lotion:

Use Cordran Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Shake well before each use.


• Apply a small amount of medicine to the affected area. Gently rub the medicine in until it is evenly distributed. Wash your hands after applying Cordran Lotion, unless your hands are part of the treated area.


• Do not bandage or cover the treated skin area unless directed by your doctor. If your doctor instructs you to bandage or cover the treated area, closely follow the instructions provided by your doctor or other health care provider.


• If you miss a dose of Cordran Lotion, apply it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not apply 2 doses at once.

Ask your health care provider any questions you may have about how to use Cordran Lotion.

Important safety information:

• Cordran Lotion is for external use only. Do not get Cordran Lotion in your eyes, nose, or mouth. If you get it in any of these areas, rinse immediately with tap water.


• Do not use Cordran Lotion on the face, underarms, or groin area unless your doctor tells you otherwise.


• If Cordran Lotion is applied to the diaper area, apply a very small amount and do not use tight-fitting diapers or plastic pants.


• Do NOT take more than the recommended dose, use Cordran Lotion longer than prescribed, or apply Cordran Lotion over a large area without checking with your doctor.


• If your symptoms do not get better within 2 weeks or if they get worse, check with your doctor.


• Talk with your doctor before you use any other medicines or cleansers on your skin.


• Check with your doctor before having vaccinations while using Cordran Lotion.


• Do not use Cordran Lotion for other skin conditions at a later time.


• Cordran Lotion contains a corticosteroid. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains hydrocortisone or any other corticosteroid. If it does or if you are uncertain, contact your doctor or pharmacist.


• Serious side effects may occur if too much of Cordran Lotion is absorbed through the skin. This may be more likely to occur if you use Cordran Lotion over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply Cordran Lotion. The risk is greater in children. Do not use more than the prescribed dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.


• Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Cordran Lotion.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cordran Lotion while you are pregnant. It is not known if Cordran Lotion is found in breast milk after topical use. If you are or will be breast-feeding while you use Cordran Lotion, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Cordran Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; burning, cracking, irritation, or peeling not present before you began using Cordran Lotion; excessive hair growth; inflamed hair follicles; inflammation around the mouth; muscle weakness; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Cordran side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face.

Proper storage of Cordran Lotion:

Store Cordran Lotion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cordran Lotion out of the reach of children and away from pets.

General information:

• If you have any questions about Cordran Lotion, please talk with your doctor, pharmacist, or other health care provider.


• Cordran Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Cordran Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Cordran resources

• Cordran Side Effects (in more detail)
• Cordran Use in Pregnancy & Breastfeeding
• Cordran Drug Interactions
• Cordran Support Group
• 0 Reviews for Cordran - Add your own review/rating

Compare Cordran with other medications

• Atopic Dermatitis
• Dermatitis
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Clevidipine

Pronunciation: klev-ID-i-peen
Generic Name: Clevidipine
Brand Name: Cleviprex

Clevidipine is used for:

Treating high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Clevidipine is a calcium channel blocker. It works by relaxing (dilating) your blood vessels and lowering blood pressure. It also dilates coronary arteries increasing blood flow to the heart.

Do NOT use Clevidipine if:

• you are allergic to any ingredient in Clevidipine


• you are allergic to soy or egg products


• you have lipid (fat) metabolism problems


• you have severe aortic stenosis (narrowing of the main artery of the heart)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clevidipine:

Some medical conditions may interact with Clevidipine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods (especially egg or soy products), or other substances


• if you have heart failure, very low blood pressure, liver problems, or pancreas problems

Some MEDICINES MAY INTERACT with Clevidipine. However, no specific interactions with Clevidipine are known at this time.

Ask your health care provider if Clevidipine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clevidipine:

Use Clevidipine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Clevidipine is usually given as an infusion at your doctor's office, hospital, or clinic.


• Do not use Clevidipine if it contains particles, is discolored, or if the vial is cracked or damaged.


• If you miss a dose of Clevidipine, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Clevidipine.

Important safety information:

• Clevidipine may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Clevidipine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Clevidipine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.


• Lab tests, including blood pressure checks, may be performed while you use Clevidipine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Clevidipine with caution in the ELDERLY; they may be more sensitive to its effects.


• Clevidipine should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clevidipine while you are pregnant. It is not known if Clevidipine is found in breast milk. If you are or will be breast-feeding while you use Clevidipine, check with your doctor.

Possible side effects of Clevidipine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; pounding in the chest; shortness of breath; sudden severe dizziness; swelling of feet or legs; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Clevidipine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness; fainting or lightheadedness, especially upon standing; very fast heart rate.

Proper storage of Clevidipine:

Clevidipine is usually handled and stored by a health care provider. If you are using Clevidipine at home, store Clevidipine as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clevidipine out of the reach of children and away from pets.

General information:

• If you have any questions about Clevidipine, please talk with your doctor, pharmacist, or other health care provider.


• Clevidipine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Clevidipine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Clevidipine resources

• Clevidipine Side Effects (in more detail)
• Clevidipine Dosage
• Clevidipine Use in Pregnancy & Breastfeeding
• Clevidipine Drug Interactions
• Clevidipine Support Group
• 0 Reviews for Clevidipine - Add your own review/rating

• clevidipine Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


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• Cleviprex Consumer Overview

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